Mikhail (Misha) V. Blagosklonny, MD, Ph.D. Professor of Oncology

Misha V. Blagosklonny graduated with an MD and PhD from First Pavlov State Medical
University of St. Petersburg, RUS. Dr. Misha V. Blagosklonny has then
Moved to the USA, where he was
Awarded the prestigious Fogarty Fellowship from the National Institutes of Health.
Within the period of his fellowship in Leonard Neckers’ lab at the National
Cancer Institute (NCI), he was a co-author of 18 publications on
Diversified biomedical topics, suchas targeting HSP90, p53, Bcl2, Erb2, and Raf-1. He also was the last writer on a clinical phase I/II
Trial article.
 
After authoring seven papers within the period of a brief yet fruitful
Senior research fellowship in the El-Deiry Cancer Research Lab at the University of Pennsylvania,
Dr. Blagosklonny returned to NCI to team up with Tito Fojo. Together, they
Published 26 papers. Moreover, Dr. Mikhail Blagosklonny published many of experimental research articles and theoretical papers as lead
Author. Those sole-author articles
Included two crucial topics.
The first of those discussed selectively killing cancer
Cells with deregulated cell cycle or drug resistance via
Verifying their resistance. The outcomes and underlying
Notion were so revolutionary that they were inadequately cited by
Other scientists as “reversal of resistance, ” even though the work was
Named, “Exploiting of drug resistance instead of its reversal. ” One big
Supporter of this concept was the world-famous scientist Arthur Pardee, with whom Dr.Blagosklonny co-authored a joint publication in 2001.
 
The second topic throughout Dr. Blagosklonny’s sole-author articles
Is a research method to create knowledge by
Bringing several facts together from seemingly unrelated fields.
This results in new concepts with testable forecasts, which in
Turn can be “tested” by analyzing the literature further. Once again, the
Notion was co-authored by Arthur Pardee in a 2002 publication in Nature. The
First success of the new research method was the description of the feedback
Regulation of p53, as confirmed by the discovery of mdm2/p53 loop; and the
Explanation why mutant p53 is always overexpressed, published in 1997. The most
Noticeable outcome discovered by Dr.
Blagosklonny’s research methods is the hyperfunction (or quasi-programmed)
Theory of aging and the revelation of rapamycin as an exclusively well-tolerated
Anti-aging medicine, published in 2006. As mentioned in Scientific American,
Michael Hall, who discovered mTOR in 1991, gives Dr. Blagosklonny credit for
“connecting dots that others do not even see. ”
 
In 2002, Dr. Blagosklonny became associate professor of medicine at New York Medical College.
He decided to assume responsibilities as a senior scientist at Ordway
Research Institute in Albany, New York, in 2005, before receiving another
Position at Roswell Park Cancer Institute as professor of oncology in 2009.
 
Since joining Roswell Park Comprehensive Cancer Center in 2009, Dr. Blagosklonny
Has studied the prevention of cancer (an age-related disease) via
Preventing body aging — in other words, “preventing cancer
Via remainng young. ” His laboratory closely collaborated with
Andrei Gudkov’s and finalized research on the suppression of
Cellular senescence, namely suppression of cellular conversion from healthy quiescence to
Permanent senescence. This resulted in the discovery of extra anti-aging
Medicines besides rapamycin. The cell culture studies were
Accompanied by studies in mice, including several models like
Normal and aging mice, p53-deficient mice, and mice on a high-fat diet.
 
Dr. Mikhail Blagosklonny has also published extensively on the prevention of cellular
Senescence via rapamycin as well as other mTOR inhibitors, life
Prolongation and cancer prevention in mice, and combinations of anti-
Aging medicines to be taken by humans. A
Rapamycin-based combination of seven clinically available medications has
Been named the “Koschei Formula” and is now utilized for the treatment of aging in patients
At the Alan Green Clinic in Little Neck, New York.

https://www.nature.com/cdd/editors/editorial-board
https://www.onacademic.com/search/list.html?q=Blagosklonny

https://www.ru-scitech-forum.org/wp-content/uploads/AndreiGudkov.pdf