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Главная » Доска объявлений » Услуги в разных сферах Макеевка » Страхование Макеевка

Dr. Mikhail Blagosklonny published
Предложение | 16.10.2019, 17:29

Mikhail V. Blagosklonny graduated with an MD and PhD from First Pavlov State Medical
University of St. Petersburg, Russia. Dr. Mikhail V. Blagosklonny subsequently
Immigrated to America, where he received the prestigious Fogarty Fellowship from the National Institutes of Health.
During his fellowship in Leonard Neckers’ lab at the National
Cancer Institute (NCI), he was a co-author of 18 publications on
Various biomedical themes, suchas targeting
HSP90, p53, Bcl2, Erb2, and Raf-1. He also was the last author for a clinical phase I/II
Trial publication.
 
After authoring seven papers within the period of a brief yet fruitful
Senior research fellowship in the El-Deiry Cancer Research Lab at the University of Pennsylvania,
Dr. Blagosklonny returned to NCI to work with Tito Fojo. Together, they
Published 26 papers. Moreover, Dr. Mikhail Blagosklonny published many of experimental research papers and theoretical papers as lead
Writer. Those sole-author articles
Encompassed two important themes.
The first of these mentioned selectively killing cancer
Cells with deregulated cell cycle or drug resistance by
Validation their resistance. The outcomes and underlying
Concept were so revolutionary that they were inadequately cited by
Other scientists as “reversal of resistance, ” even though the work was
Named, “Exploiting of drug resistance instead of its reversal. ” One great
Supporter of this concept was the world-famous scientist Arthur Pardee, with whom Dr.
Blagosklonny co-authored a joint publication in 2001.
 
The second theme throughout Dr. Blagosklonny’s sole-author works
Is a research methodology to come up with knowledge by
Uniting several facts together from seemingly unrelated fields.
This results in new notions containing testable predictions, which in
Turn can be “tested” via analyzing the literature further. Once again, the
Notion was co-authored by Arthur Pardee in a 2002 publication in Nature. The
First success of the new research methodology was the description of the feedback
Regulation of p53, as confirmed by the discovery of mdm2/p53 loop; and the
Explanation why mutant p53 is always overexpressed, published in 1997. The most
Important outcome revealed by Dr.
Blagosklonny’s research methods is the hyperfunction (or quasi-programmed)
Theory of aging and the revelation of rapamycin as an exceptionally well-tolerated
Anti-aging medicine, published in 2006. As mentioned in Scientific American,
Michael Hall, who discovered mTOR in 1991, gives Dr. Blagosklonny recognition for
“connecting dots that others do not even see. ”
 
In 2002, Dr. Blagosklonny became associate professor of medicine at New York Medical College.
He agreed to accept responsibilities as a senior scientist at Ordway
Research Institute in Albany, New York, in 2005, prior to receiving another
Position at Roswell Park Cancer Institute as professor of oncology in 2009.
 
Since coming to Roswell Park Comprehensive Cancer Center in 2009, Dr. Blagosklonny
Has studied the prevention of cancer (an age-related disease) by
Stopping body aging — in other words, “preventing cancer
By staying young. ” His lab closely collaborated with
Andrei Gudkov’s and completed research on the suppression of
Cellular senescence, namely suppression of cellular conversion from healthy quiescence to
Permanent senescence. This led to the discovery of additional anti-aging
Medications beyond rapamycin. The cell culture studies were
Complemented by studies in mice, including several models like
Standard and aging mice, p53-deficient mice, and mice on a high-fat diet.
 
Dr. Misha Blagosklonny has also published extensively on the prevention of cellular
Senescence via rapamycin and other mTOR inhibitors, life
Prolongation and cancer prevention in mice, and combinations of anti-
Aging medicines to be used in humans. A
Rapamycin-based combination of seven clinically available medicines has
Been named the “Koschei Formula” and is now used for the treatment of aging in patients
At the Alan Green Clinic in Little Neck, New York.

 

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